Plasmacytoid DCs Induce Gutsy Plasma Cells

Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs

Antiviral cell-mediated immunity is initiated by the dendritic cell (DC) network in lymph nodes (LNs). Plasmacytoid DCs (pDCs) are known to migrate to inflamed LNs and produce interferon (IFN)-alpha, but their other roles in antiviral T cell immunity are unclear. We report that LN-recruited pDCs are activated to create local immune fields that generate antiviral cytotoxic T lymphocytes (CTLs) i...

HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism.

Plasmacytoid DCs (pDCs) have been implicated as crucial cells in antiviral immune responses. On recognizing HIV, they become activated, secreting large amounts of IFN-alpha and inflammatory cytokines, thereby potentiating innate and adaptive antiviral immune responses. Here, we have shown that HIV-stimulated human pDCs can also induce the differentiation of naive CD4+ T cells into Tregs with su...

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6.

Dendritic cells (DCs) initiate and control immune responses. Plasmacytoid DCs (pDCs) represent a unique DC subset able to promptly release large amounts of type I interferon (IFN-alphabeta) upon viral encounter. Here we report that depletion of pDCs from human blood mononuclear cells abrogates the secretion of specific and polyclonal IgGs in response to influenza virus. Furthermore, purified pD...

Plasmacytoid Dendritic Cells Induce the Thymic Stromal Lymphopoietin-Activated

Differential requirement for DOCK2 in migration of plasmacytoid DCs versus myeloid DCs

Correspondence: Yoshinori Fukui, Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan e-mail: [email protected] phone: 81(Japan)-92-642-6828 fax: 81(Japan)-92-632-0150 Blood First Edition Paper, prepublished online January 15, 2008; DOI 10.1182/blood-2007-09-...